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Medical science has been one of the most fascinating field in the industry. It has answered several questions regarding medical diseases and most importantly discovered several treatments for the many physical diseases of human. Clodronate liposome for example, are one of those remarkable discoveries which could play a great role in medicine.
Apart from cardiovascular and metabolic diseases, autoimmune diseases and cancer are among the common medical condition of people through out the world. What's worse is that both diseases remains to be incurable as all present therapies focuses on how to slow down the progression or worsening of the disease.
It activates the process of T and B lymphocytes, meaning they are the ones that can activate the immune system to work. Such phenomenon though is a good thing as it defends human from getting sick such as flu or any another viral diseases. But, this could also be a bad thing especially to those that have autoimmune diseases or to people that just had a transplant operation.
Transplant surgery often face the risk of transplant rejection, wherein the patient's immune system will attack the transplanted organ. As the immune system becomes overly reactive this will soon bring forth medical conditions, hence the term autoimmune diseases. This includes systemic lupus erythematosus, rheumatoid arthritis, grave's disease, Sjogren's syndrome, multiple sclerosis, prenicious anemia and many others. Autoimmune diseases, transplantation and cancer are one of the most common condition that indicates increased phagocytotic activity.
Indeed, the macrophage cells are termed to be the most important factor in the immune system. Such cells attack bacteria or virus through phagocytosis. Phagocytosis is the ingesting and digesting of bacteria and other cells which are foreign to the body. Phagocytosis is the process that actively defends the body every single day and whenever one is exposed to active viruses.
Through the breakthrough component, clodronate liposome there will be a greater chance to suppress immune activity hence preventing or slowing down disease progression. Clodronate is a bisphosphonate that proved to effectively deplete macrophage thus decreasing phagocytosis. Liposomes acts as the vehicle for the active component to enter into the body.
To be able to manage such conditions, medical experts have stumbled upon clodronate, accidentally. Such experimental medicine is a bisphosphonate that is said to effectively deplete macrophage. Though the artificial lipid and drug vehicle liposome, clodronate is transported into the body. As soon as the macrophage detect such active drug as "foreign" this will automatically engulf it through phagocytosis.
As soon as the active component is released inside the macrophage cell, it will cause apoptosis, or in other words, cell death. With the death of macrophage cells, this will suppress the immune system. This is why, such component has shown promising results towards reducing disease progression of patients with autoimmune disease as well as prevent transplant rejection.
Several research conclusions have made clodronate liposome a promising therapeutic agent for humans affected with cancer and autoimmune diseases. Such component was said to have a significant role in cardiovascular diseases as well and that includes myocardial infarction.
Apart from cardiovascular and metabolic diseases, autoimmune diseases and cancer are among the common medical condition of people through out the world. What's worse is that both diseases remains to be incurable as all present therapies focuses on how to slow down the progression or worsening of the disease.
It activates the process of T and B lymphocytes, meaning they are the ones that can activate the immune system to work. Such phenomenon though is a good thing as it defends human from getting sick such as flu or any another viral diseases. But, this could also be a bad thing especially to those that have autoimmune diseases or to people that just had a transplant operation.
Transplant surgery often face the risk of transplant rejection, wherein the patient's immune system will attack the transplanted organ. As the immune system becomes overly reactive this will soon bring forth medical conditions, hence the term autoimmune diseases. This includes systemic lupus erythematosus, rheumatoid arthritis, grave's disease, Sjogren's syndrome, multiple sclerosis, prenicious anemia and many others. Autoimmune diseases, transplantation and cancer are one of the most common condition that indicates increased phagocytotic activity.
Indeed, the macrophage cells are termed to be the most important factor in the immune system. Such cells attack bacteria or virus through phagocytosis. Phagocytosis is the ingesting and digesting of bacteria and other cells which are foreign to the body. Phagocytosis is the process that actively defends the body every single day and whenever one is exposed to active viruses.
Through the breakthrough component, clodronate liposome there will be a greater chance to suppress immune activity hence preventing or slowing down disease progression. Clodronate is a bisphosphonate that proved to effectively deplete macrophage thus decreasing phagocytosis. Liposomes acts as the vehicle for the active component to enter into the body.
To be able to manage such conditions, medical experts have stumbled upon clodronate, accidentally. Such experimental medicine is a bisphosphonate that is said to effectively deplete macrophage. Though the artificial lipid and drug vehicle liposome, clodronate is transported into the body. As soon as the macrophage detect such active drug as "foreign" this will automatically engulf it through phagocytosis.
As soon as the active component is released inside the macrophage cell, it will cause apoptosis, or in other words, cell death. With the death of macrophage cells, this will suppress the immune system. This is why, such component has shown promising results towards reducing disease progression of patients with autoimmune disease as well as prevent transplant rejection.
Several research conclusions have made clodronate liposome a promising therapeutic agent for humans affected with cancer and autoimmune diseases. Such component was said to have a significant role in cardiovascular diseases as well and that includes myocardial infarction.
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